从证候分子本质论食管癌血瘀病机

Discussion on Pathogenesis on Blood Stagnation of Esophageal Carcinoma from Molecular Essence of Syndrome

瘀血体质、体内血瘀不祛,是食管癌发生的重要内环境。通过总结古代医家有关食管癌血瘀病机的认识,结合基础实验研究,并利用方证关系理论,文章对食管癌血瘀病机的分子本质进行了分析讨论,以确定血瘀病机的证候分子标志物。EGFR、PI3K/AKT和Caspase-3信号通路蛋白表达的异常与血瘀病机密切相关,可以为食管癌的瘀血证分子诊断提供参考。

Constitution of blood stasis and generation of stagnation are important internal circumstances for esophageal cancer.Through summary on literatures of blood-stasis pathogenesis on esophageal cancer in ancient China,combined with experiments results,discussion on molecular essence of stagnation syndrome is investigated with theory of relations between syndrome and formula.Molecular markers for blood-stasis are located,including EGFR,several key proteins in signal pathways mediated by PI3K/AKT and Caspase-3.The results may provide reference for diagnosis on esophageal cancer.