尼莫地平联合多奈派齐治疗轻中度血管性痴呆的疗效观察

目的观察尼莫地平联合多奈派齐治疗血管性痴呆的疗效。方法将116例患者随机分为两组:治疗组58例,尼莫地平联合多奈派齐治疗;对照组58例,尼莫地平治疗。于治疗前及治疗后第18周,分别用简易精神状态量表(MMSE)和日常生活活动能力量表(ADL)进行评定。结果治疗后第18周,两组MMSE、ADL评分比治疗前明显提高,差异显著(P<0.05);治疗组与对照组ADL评分差异有统计学意义(P<0.05)。结论尼莫地平联合多奈派齐治疗血管性痴呆有良好的疗效。

Objective To investgate the effect of nimodipine with donepezil on mild to moderate vascular dementia. Methods 116 patients were randomLy divided into 2 groups treatment group （n=58）and control group （n=58）. In treatment group, patients accepted nimodipine and donepezil orally.In control group, patients accepted nimodipine only. Before treatment and 18 weeks after treatment, respectively mini-mental state examination （MMSE） and activities of daily living scale （ADL） of patients were evaluated.Results 18 weeks after treatment, the MMSE, ADL scores in every group significantly improved compared with that of before treatment（P〈0.05）. Compared with control group,the ADL score in treatment group were significantly elevated（P〈0.05）. Conclusion Nimodipine with donepezil had a good effect on vascular dementia.