黑米花青苷复方胶囊对酒精性肝损伤的防治作用

Preventive and curative effect of black rice anthocyanin compound capsule on alcohol-induced liver injury

目的:研究黑米花青苷复方胶囊在小鼠酒精性肝损伤中的防治作用。方法:建立小鼠酒精性肝损伤病理模型,分别灌胃低剂量、高剂量的黑米花青苷复方胶囊进行治疗,正常组灌胃蒸馏水,助悬剂组灌胃植物油。第12d,测定肝组织中超氧化物歧化酶(SOD)活力、丙二醛(MDA)含量、谷胱甘肽(GSH)含量及肿瘤坏死因子-α(TNF-α)和白介素-lβ(IL-lβ)的水平,并进行肝脏病理学观察。结果:黑米花青苷复方胶囊能明显提高肝组织中SOD的活力,对MDA起到直接清除作用;还可以提高GSH含量,降低TNF-α和IL-lβ的水平。病理组织学显示,黑米花青苷胶囊能显著改善肝细胞的脂肪变性。同时,助悬剂对药物的效果没有影响。结论:黑米花青苷复方胶囊能够对酒精性肝损伤的治疗起到一定的效果。

Established pathology model of alcoholic-induced liver injury in mice and cured by poured the black rice anthocyanin compound capsule in low concentration and high concentration into stomach,distilled water for the normal group and plant oil for the suspending agents group. The content of SQD,MDA,GSH and the levels of TNF-α＆IL-Iβ in liver homogenate were measured in the 12th day. Hepatic pathological examination was observed. The result showed that the black rice anthocyanin compound capsule could increase S＊D activity obviously,clear MDA content directly in hepatic tissue,improve GSH content and reduce TNF-α＆IL-Iβ level and improve hepatic steatosis. At the same time,suspension agents basically had no influence on drug effect. Therefore the black rice anthocyanin compound capsule had a particular treatment effect on alcohol liver injury in mice.