摘要
A practical one-pot protocol for the synthesis of 2,5-disubstituted oxazoles from 1-aryl-2-nitroethanones was reported. In the presence of iron/AcOH in acetonitrile, the reaction of 1-aryl-2-nitroethanones with trimethyl orthoacetate or trimethyl orthobenzoate delivered the corresponding 2,5-disubstituted oxazoles in moderate to good yields.
A practical one-pot protocol for the synthesis of 2,5-disubstituted oxazoles from 1-aryl-2-nitroethanones was reported. In the presence of iron/AcOH in acetonitrile, the reaction of 1-aryl-2-nitroethanones with trimethyl orthoacetate or trimethyl orthobenzoate delivered the corresponding 2,5-disubstituted oxazoles in moderate to good yields.
基金
Supporting information for this article is available on the WWW under http：//dx.cloi.org/10, 1002/cjoc.201100683 or from the author. AcknowledgementWe thank the National Natural Science Foundationof China （Nos. 20872087, 21002061, 20902057, 21142012）, the State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Leading Academic Discipline Project of Shanghai Municipal Education Commission （No. J50101）, and the Graduate Innovation Fund of Shanghai University for financial support. We thank Dr. Hongmei Deng （Laboratory for Microstructures, Shanghai University） for NMR measurements. We are indebted to Professor Ran Hong of SIOC for enlightening discussions.
