摘要
Two novel 5-fluorouracil derivatives of rare earth （Sm, Eu） substituted polyoxometalates, K9（C4H4FN2O2）2- Sm（PW11O39）2·11H2O （FSmPW） and KgH（C4H4FN2O2）Eu（PW11O39）2＊11 H2O （FEuPW） were synthesized and characterized by element analysis, ICP, FT-IR, 1H NMR and XRD analysis. Thermal stability analysis was performed by TG and FT-IR. The results of MTT assay show that FSmPW and FEuPW have higher cytotoxicity than known compound C4H4FN2O2H2PW12O40＊8H2O, and the IC50 values of FSmPW and FEuPW are 4.20, 3.49 μmol· L ^-1 against HeLa cells and 4.62, 7.19 μmol· L ^-1 against HepG-2 cells. Apoptosis analysis reveals the apoptosis inducing activity of the two compounds, which may play an important role in the cytotoxieity of polyoxometalates.
Two novel 5-fluorouracil derivatives of rare earth （Sm, Eu） substituted polyoxometalates, K9（C4H4FN2O2）2- Sm（PW11O39）2·11H2O （FSmPW） and KgH（C4H4FN2O2）Eu（PW11O39）2＊11 H2O （FEuPW） were synthesized and characterized by element analysis, ICP, FT-IR, 1H NMR and XRD analysis. Thermal stability analysis was performed by TG and FT-IR. The results of MTT assay show that FSmPW and FEuPW have higher cytotoxicity than known compound C4H4FN2O2H2PW12O40＊8H2O, and the IC50 values of FSmPW and FEuPW are 4.20, 3.49 μmol· L ^-1 against HeLa cells and 4.62, 7.19 μmol· L ^-1 against HepG-2 cells. Apoptosis analysis reveals the apoptosis inducing activity of the two compounds, which may play an important role in the cytotoxieity of polyoxometalates.
