检测血清可溶性E-钙粘连蛋白在卵巢癌手术前后的表达及其意义

Expression and its clinical significance of serum soluble E-cadherin before and after operation in ovarian cancer patients

目的检测卵巢癌患者手术治疗前后血清可溶性E-钙粘连蛋白(E-cad)的表达,探讨其临床意义。方法采用酶联免疫吸附(ELISA)方法检测32例卵巢癌患者手术前后及30例健康人血清E-cad的水平。分析卵巢癌术前血清E-cad的水平与临床病理特征的关系。结果卵巢癌患者术前血清E-cad水平显著高于健康人,手术1周后血清E-cad水平较术前显著下降。术前血清E-cad水平与卵巢癌临床分期显著相关,与病理类型、病理分级、腹水、淋巴结转移无显著相关。结论卵巢癌术前血清E-cad水平与临床分期有关,可作为一种卵巢癌预后预测因子。

Objective To detect expression of serum soluble E -cadherin （sEC） before and after operation in ovarian cancer patients, and to dicuss its clinical significance. Methods The levels of sEC in 32 ovarian cancer patients were tested by enzyme linked immunosorbent assay（ELISA） before and after operation as well as in 30 healthy controls. Its correlation with clinical and pathological factors was analyzed. Results The levels of sEC in ovarian cancer patients before operation were significantly higher than in controls ,which declined significantly one week ＇after operation. The of sEC levels before operation showed significant correlation with clinical stages ,which showed no significant correla- tion with factors such as pathological type, pathological grade, ascites and lymph node metastasis. Conclusion The levels of sEC in ovarian cancer patients before operation is closely related with clinical stages, which may be a predictive factor for prognosis of ovarian cancer.