尼莫地平干预治疗中老年原发性失眠的疗效观察

Effective observation on nimodipine intervention for treating middle and old age primary insomnia

目的探讨尼莫地平干预治疗中老年原发性失眠的作用。方法选择60例中老年原发性失眠患者,随机分为干预组和对照组。对照组给予常规按需服用艾司唑仑片,干预组在常规按需服用镇静催眠药基础上,加用尼莫地平干预治疗。比较两组治疗前与治疗后1个月匹茨堡睡眠质量指数量表(PSQI)评分情况及艾司唑仑用量。结果给予尼莫地平干预治疗后,患者PSQI评分及艾司唑仑用量下降差值均比对照组明显,差异有统计学意义(P<0.05)。结论尼莫地平干预治疗有助于改善中老年原发性失眠患者的临床症状,减少苯二氮类药物的用量。

Objective To explore the effect of nimodipine intervention in the treatment of middle and old age primary insomnia. Methods 60 cases of middle and old age primary insomnia were chosen and randomly divided into the intervention group and the control group. On the basis of convetional taking sedative-hypnotic drugs,the intervention group was added ni- modipine intervention. The scores of the Pittsburgh Sleep Quality Index（PSQI） and the dosage of estazolam before treatment and in 1 month after treatment were compared between 2 groups. Results After one-month intervention treatment,the PSQI scores and the dosage of benzodiazepines in the intervention group were significantly decreased, showing statistical difference compared with the control group （P〈0.05）. Conclusion Nimodipine intervention treatment can improve the clinical symptoms of middle and old age primary insomnia, and reduces the dosage of benzodiazepines.