金银花洗液治疗口服索拉菲尼并发手足水疱的效果及护理

Nursing and effect of honeysuckle lotion on the patients taking sorafenib with the complication of hand and foot blisters

目的探讨金银花洗液治疗原发性肝癌患者服用索拉菲尼后并发手足水疱的效果，并给予相应的护理。方法选取口服索拉菲尼后发生手足水疱患者45例为研究对象，按随机数字表法将其分为实验组23例和对照组22例，对照组患者采用尿素软膏外涂，实验组患者在此基础上，给予金银花洗液浸泡。比较两组患者疗效及愈合时间。结果治疗后实验组治疗有效率为91．3％，优于对照组的59．1％，差异有统计学意义（x2=8．494，P〈0．05）；实验组创面愈合时间为（8．5±4．2）d，优于对照组的（11．8±6．3）d，差异有统计学意义（t=2．92，P〈0．05）。结论金银花洗液对促进原发性肝癌患者服用索拉菲尼后并发手足水疱愈合有明显效果，且缩短愈合时间。

Objective To explore the effect of honeysuckle lotion on the primary hepatic cancer patients taking sorafenib with the complication of hand and foot blisters. Methods Totals of 45 patients who took sorafenib and complicated with the hand and foot blisters were randomly divided into experimental group （ n = 23） and control group （ n = 22）. The experimental group were soaked in honeysuckle lotion accompany with topical urea ointment, while control group received topical urea ointment. Then, the clinical effective and healing time of two groups were observed. Results There was no significant difference detected in age, lesion and general between two groups. The clinical treatment effective rate of experimental group was 91.3% significantly better than 59.1% that of control group （ x2 = 8. 494, P 〈 0.05 ）. The healing time of experimental group was （ 8.5 ± 4.2） d and that of control group was （ 11.8± 6.3 ） d, and the difference was statistically significant （ t = 2.92, P 〈 0.05 ）. Conclusions The honeysuckle lotion application can promote wound healing for primary hepatic cancer patients taking sorafenib with the complication of hand and foot blisters. And it is worthy for clinical application.