毛花甙丙联合美托洛尔治疗重度二尖瓣狭窄伴急性肺水肿的疗效观察

Effective Observation of Cedilanid and Metoprolol to Patients with Severe Mitral Stenosis Accompany with Atrial Fibrillation and Acute Pulmonary Edema

目的:探讨静注毛花甙丙和美托洛尔治疗风湿性二尖瓣重度狭窄并心房颤动、急性肺水肿患者的疗效。方法:将风湿性二尖瓣重度狭窄并心房颤动、左心室无扩大、左心室射血分数>60%、无美托洛尔禁忌证的60例急性肺水肿患者随机分为对照组和治疗组各30例,在常规治疗基础上,对照组应用毛花甙丙0.4 mg稀释后静脉注射,治疗组另加美托洛尔4 mg稀释后静脉注射,比较两组治疗60 min后的临床疗效。结果:治疗组有效率93.3%显著高于对照组的73.3%(P<0.01)。结论:静注毛花甙丙和美托洛尔治疗左心室射血分数>60%、左心室无扩大的风湿性二尖瓣重度狭窄并心房颤动、急性肺水肿的疗效好。

Objective： To explore the effect of intravenous cedilanid and metoprolol to patients with rheumatic severe mitral stenosis （MS） accompany with atrial fibrillation （AF） and acute pulmonary edema. Methods： 60 patients with rheumatic severe MS accompany with AF, the left ventricle without expanding, left ventricular ejection fraction 〉60% ,without the use of metoprolol contraindications were randomly divided into the control group and treatment group, and each group was 30 cases. Beside both the group were accepted routine treatment of acute pulmonary edema,the control group was treated by cedilanid 0.4mg dilution after intravenous injection, and the treatment group was treated by cedilanid 0.4 mg and metoprolol 4mg dilution after intravenous injection. The clinical effects were compared between the two groups after 60 minutes treatment. Results： The effective rate （93.3%） in the treatment group was significantly higher than that （73.3%） in the control group （P 〈 0.01）. Conclusion： There is better effect on the left ventricular ejection fraction 〉 60%, the left ventricle without expansion of rheumatic severe MS accompany with AF and acute pulmonary edema treated by intravenous cedilanid and metoprolol.