丙氨酰谷氨酰胺在创伤性急性肺损伤机械通气治疗中的临床研究

Clinical Research of Alanyl-glutamine' s in the Mechanical Ventilation Treatment of Traumatic Acute Lung Injury

目的:探讨丙氨酰谷氨酰胺(Ala-Gln)在创伤性急性肺损伤(ALI)机械通气治疗中的临床疗效。方法:将创伤性ALI机械通气患者60例随机分为观察组(n=30)和对照组(n=30),观察组在常规治疗基础上加Ala-Gln 0.5 g/(kg·d),连用7 d,比较两组的PaO_2、氧合指数、APACHEⅡ评分、机械通气时间、住ICU时间、ARDS发生率及病死率。结果:观察组治疗后PaO_2、氧合指数、APACHEⅡ评分、机械通气时间、住ICU时间、ARDS发生率组均明显优于对照组(P均<0.05),但病死率无显著性差异(P>0.05)。结论:Ala-Gln在创伤性ALI机械通气治疗中可能有肺保护作用,适合创伤性ALI的治疗。

Objective： To explore the clinical efficiency of alanyl-glutamine （Ala-Gln） in the mechanical ventilation treatment of traumatic acute lung injury （ALI）. Methods： 60 patients with traumatic ALI and mechanical ventilation were randomly divided into observe group （n=30） and control group （n=30）. Besides conventional treatment ,the cases in observe group were given Ala-Gln 0.5g/（kg.d） for 7 days. Blood gas analysis, oxygenation index, APACHE lI score, the time for mechanical ventilation, the time for ICU, the number of cases developed into ARDS and mortality were compared between the two groups. Results： The PaO2, oxygenation index, APACHE II score, the time for mechanical ventilation time, the time for ICU, the ARDS incidence in the observe group were significantly better than those in the control group （all P〈0.05）.But the mortality was no significant difference between the two groups （P〉0.05）. Conclusion： Ala-Gln in the mechanical ventilation treatment of traumatic ALl may have the efficiency of lung protection and may be suitable for treatment of the disease.