急性化脓性阑尾炎围术期应用抗菌药物调查及药物经济学研究

Investigation and Pharmacoeconomics Research on Perioperative Antimicrobials Application in Acute Suppurative Appendicitis

目的通过了解急性化脓性阑尾炎围术期抗菌药物预防性使用情况,规范使用抗菌药物。方法回顾性调查2009-01～2011-12急性化脓性阑尾炎手术患者88例,对其应用抗菌药物的品种、用法用量、治疗成本、用药成本及疗效等进行评价分析。结果 88例急性化脓性阑尾炎手术患者抗菌药物应用率100%;3组方案预防急性阑尾炎术后感染的疗效分别为:98.19%、100%、100%(P>0.05),其治疗成本分别为:5 425.36±1 349.11、7 791.17±1 794.70、5 766.25±1 280.46。结论急性化脓性阑尾炎围术期在抗菌药物种类选择、持续用药时间等方面仍存在不合理现象,应加强临床合理用药的干预。

Objective By understanding the application of perioperative antibacterials in acute suppurative appendicitis, to standardize the application of antimicrobials. Methods A total of 88 cases of acute suppurative appendicitis from January 2009 to December 2011 were retrospectived surveyed, evaluating the type of antimicrobials application, way and dosage of application, treatment costs, drug costs and treatment efficacy. Results The antimicrobials application rate of 88 cases of acute suppurative appendicitis surgery was 100%. The efficiency rate of 3 groups was 98.19%, 100%, and 100% , respectively （P 〉0.05）, and the cost of treatment was 5 425.36 ± 1 349.11, 7 791.17 ± 1 794.70, 5 766.25 ± 1 280.46. Conclusion There are still irrational phenomenons in the selection of antimicrobials types in acute suppurative appendicitis perioperative and of the duration of drug application, we should strengthen the clinical rational drug application intervention.