依达拉奉对脑出血患者部分炎性细胞因子水平的影响研究

The influence of edaravone on serum IL-6、TNF-α、ET、sICAM-1 and MCP-1 in acute intracerebral hemorrhage patients

目的 探讨依达拉奉对脑出血患者血清白细胞介素-6（IL-6）、肿瘤坏死因子α（TNF-α）、内皮素（ET）、可溶性细胞间黏附分子（sICAM-1）和单核细胞趋化因子（MCP-1）的影响以及临床疗效,探讨依达拉奉对脑出血的保护机制。方法 选择急性脑出血患者100例,随机分为治疗组和对照组各50例,对照组给予常规治疗,治疗组则在常规治疗基础上加用依达拉奉30 mg/d,治疗10 d,采用ELESA法检测血清中IL-6、TNF-α、ET、sICAM-1及MCP-1的水平,并进行神经功能缺损评分;并以30例健康体检者作为健康组进行对照。结果 脑出血患者血清IL-6、TNF-α、ET、sICAM-1及MCP-1水平较健康组明显升高（P〈0.05）;治疗后两组血清IL-6、TNF-α、ET、sICAM-1及MCP-1水平均较治疗前明显下降（均P〈0.05）,且治疗组较对照组下降明显（P〈0.05）;两组NDS评分较治疗前明显下降（均P〈0.05）,且治疗组较对照组下降明显（P〈0.05）。结论 依达拉奉可显著降低急性脑出血患者IL-6、TNF-α、ET、sICAM-1及MCP-1的表达,减轻脑组织炎性反应和脑损伤,改善神经功能缺损,对脑细胞起到保护作用。

Objective To study the influence of edaravone on serum IL-6,TNF-α,ET,sICAM-1 and MCP-1 in acute cerebral hemorrhage patients,discuss the protective mechanism of edaravone on cerebral hemorrhage.Methods 100 patients with acute cerebral hemorrhage were randomly divided into treatment group and control group（50 cases）,the serum levels of IL-6,TNF-α,ET,sICAM-1 and MCP-1 were detcted by ELSA at pretherapy and after given treatment.Neurological functional deficit scores were utilized for assessment at pretherapy and after given treatment.A healthy control group which approximately matched the experimental group included 30 persons.ResultsThe levels of serum IL-6,TNF-α,ET,sICAM-1 and MCP-1 in both two groups after treatment were significantly lower than those before treatment（all P〈0.05）,and the levels of serum IL-6,TNF-α,ET,sICAM-1 and MCP-1 in edaravone therapy group significantly lower those that in conventional therapy group（P〈0.05）.NDS of both groups after treatment were lower than those before treatment（P〈0.05）,and the scores of edaravone therapy group were significantly lower than those of conventional therapy group（P〈0.05）.Conclusion Edaravone can decrease the levels of IL-6,TNF-α,ET,sICAM-1 and MCP-1 in patients with acute cerebral hemorrhage.It could lighten acute inflammation and brain injured,lessen nerve function impairment,and protect the tissue of brain.