可溶性Apo-1/Fas对结核性和恶性胸腔积液的鉴别诊断价值

The significance of the soluble Apo-1/Fas in serum and pleural effusion in differentiating tuberculous and malignant pleural effusion

目的 通过检测血清及胸水中可溶性Apo-1/Fas（sApo-1/Fas）的水平,探讨其对鉴别良恶性疾病的意义。方法 采用酶联免疫吸附法（ELISA）法检测50例恶性胸腔积液患者和48例结核性胸腔积液患者血清和胸水中sApo-1/Fas的含量。结果 恶性胸腔积液患者血清和胸水中sApo-1/Fas的含量分别为（16.3±2.5）μg/L、（38.6±13.5）μg/L,均明显高于结核性胸腔积液组（均P＜0.05）。两组胸水/血清sApo-1/Fas比值差异有统计学意义（P＜0.05）。血清sApo-1/Fas＋胸水sApo-1/Fas对恶性胸腔积液诊断的敏感度为66.0%、特异度为93.8%、准确度为79.6%。结论 血清和胸水中sApo-1/Fas的测定有利于良恶性胸水的鉴别。

Objective To investigate the significance of the soluble Apo-1/Fas（sApo-1/Fas） in differentiating tuberculous and malignant pleural effusion.Methods The level of sApo-1/Fas was detected by enzyme linked immunosorbent assay（ELISA）.in serum and pleural effusion of 50 cases with malignant pleural effusion and 48 cases with tuberculous pleural effusion.Results The level of sApo-1/Fas in the serum and pleural effusion of malignant pleural effusion patients were （16.3±2.5）μg/L and （38.6±13.5）μg/L,significantly higher than those of tuberculous patients with pleural effusion（all P＜0.05）.The difference of rates of serum and pleural effusion in malignant pleural effusion and tuberculous pleural effusion patients was significant（P＜0.05）.The sensitivity,specificity and accuracy of sApo-1/Fas in serum and malignant pleural effusion were 66.0% and 93.8% and 79.6%.ConclusionThe detecting of sApo-1/Fas may play some role in differentiating tuberculous and malignant pleural effusion.