2型糖尿病视网膜病变患者同型半胱氨酸、血管内皮生长因子和脂联素的检测及意义

The detection and signicance of homocysteine,vascular endothelial growth factor and adiponectin levels in type 2 diabetic patients with diabetic retinopathy

目的 研究2型糖尿病视网膜病变（DR）患者血清同型半胱氨酸（Hcy）、血管内皮生长因子（VEGF）和脂联素的水平变化及临床意义。方法 选择60例糖尿病视网膜病变患者（DR组）和单纯糖尿病无视网膜病变患者（NDR组）40例,另选择健康体检者30例作为对照（对照组）,采用酶联免疫分析法（ELISA）检测血清Hcy、VEGF和脂联素水平并比较。结果 DR组和NDR组患者血清Hcy和VEGF水平均明显高于正常对照组（均P〈0.05）,DR组血清Hcy和VEGF水平均高于NDR组（均P〈0.05）。而DR组和NDR组患者血清脂联素水平均明显低于对照组（均P〈0.05）,DR组血清脂联素水平低于NDR组（均P〈0.05）。血清脂联素与Hcy和VEGF呈负相关（均P〈0.05）。结论 Hcy、VEGF和脂联素可能参与了糖尿病视网膜病变的发病机制,可能在糖尿病视网膜病变发展中起重要作用。

Objective To investigate the change of homocysteine＆nbsp; level,vascular endothelial growth factor（VEGF） and adiponectin levels in type 2 diabetic patients with diabetic retinopathy and its signicance.Methods 60 patients with diabetic retinopathy（DR group）and 40 patients with normal fundus（NDR goup）were selected.30 healthy subjects were used as control group.The serum levels of Hcy,VEGF and adiponectin were detected.ResultsThe serum levels of Hcy and VEGF of DR group and NDR goup patients were higher than that of control group and had statistical significance（all P〈0.05）;The serum levels of Hcy and VEGF of DR group were higher than that of NDR group（all P〈0.05）.The serum level of adiponectin of DR group and NDR goup patients was lower than that of control group（all P〈0.05）;The serum level of adiponectin of DR group was lower than that of NDR group（all P〈0.05）.Hcy and VEGF had a positive correlation with adiponectin（all P〈0.05）.Conclusion Hcy,VEGF and adiponectin may play important roles in the initiation and sustainment of DR.