热毒宁注射剂与阿昔洛韦配伍的稳定性研究

Compatible stability of Reduning Injection with acyclovir

目的探索热毒宁注射液与阿昔洛韦配伍的稳定性。方法在室温25℃观察两种药物混合液在60min内的外观、pH值、光谱图变化。结果两种药物较高浓度混合液会立即出现浑浊和颜色改变,较低浓度混合液的外观清澈透明、微黄;低浓度混合液60min内的pH值稳定;各时间点的吸光度值显著下降,质量分数明显减少。结论热毒宁注射液与阿昔洛韦无论浓度高低均存在配伍禁忌,建议避免混合应用。

Objective To investigate the compatible stability of Reduning Injection with acyclovir. Methods Changes of appearance, pH value and absorption spectrum in the mixture of Reduning Injection with acyclovir were observed at room temperature （25 ℃） for 60 min. Results The mixture became turbid and the color changed immediately when the concentrations of Reduning Injection with acyclovir was higher. While at the lower concentration, the mixture was clear, its color became a little yellow, and the pH value was stable during 60 rain;. The absorbance value dropped in different time points, which meant the relative content of each component decreased. Conclusion Reduning Injection should be avoided to use with acyclovir for the imcompatibility between them no matter the concentration is high or not.