丁咯地尔联合丹参川芎嗪注射液治疗后循环缺血性眩晕的疗效

Effects of combined treatment with buflomedil injection,and Salviae Miltiorrhizae and Ligustrazine Hydrochloride injection on posterior circulation ischemic vertigo

目的:观察丁咯地尔联合丹参川芎嗪注射液治疗后循环缺血性眩晕的临床疗效。方法:将120例后循环缺血性眩晕患者随机分为2组,丁咯地尔联合丹参川芎嗪治疗组(60例)和丹参川芎嗪治疗组(60例)。观察2组患者治疗前及治疗14d后,前后椎动脉(VA)及基底动脉(BA)的平均血流速度(Vm)变化及治疗14d后的临床疗效和不良反应。结果:联合治疗组总有效率91.6%,显著高于丹参川芎嗪治疗组(总有效率83.3%,P<0.05)。治疗前后经颅多普勒检测结果,治疗前2组血流速度比较无显著性差异(P>0.05),用药后2组血流速度均显著增快(P<0.05),联合治疗组血流速度增快更显著(P<0.05)。结论:丁咯地尔联合丹参川芎嗪注射液能快速、有效地治疗后循环缺血性眩晕。

Objective：To explore the clinical curative effects of combined treatment with buflomedil injection and Salviae Miltiorrhizae and Ligustrazine Hydrochloride（SM＆LH）injection on posterior circulation ischemic vertigo.Methods：Patients with posterior circulation ischemic vertigo were randomly divided into combined treatment group（n=60） and SM＆LH injection group（n=60）.All 120 patients were treated with SM＆LH injection.On this basis,the patients in combined treatment group were treated with buflomedil injection.Cerebral hemodynamics,including left vertebral artery,right vertebral artery and basilar artery were examined before the treatment and 14 days after the treatment.Clinical effects and adverse reactions were observed after the treatment.Results：The total effective rate of combined treatment group were significantly higher than that of SM＆LH injection group（P〈0.05）.Compared with SM＆LH injection group,blood flow velocity of posterior circulation increased significantly in combined treatment group after treatment（P〈0.05）.Conclusion：It is effective to treat posterior circulation ischemic vertigo with buflomedil injection and SM＆LH injection.