2型糖尿病患者血清脂联素水平与踝肱指数的相关性研究

Study on correlation between serum adiponectin level and ankle brachial index in type 2 diabetes mellitus

目的研究T2DM患者APN水平与踝肱指数(ABI)的关系,并探讨APN和ABI的相关影响因素。方法 118例T2DM患者根据ABI分为外周血管病变(PAD)组和非PAD组,进行APN及临床指标的测定。结果 (1)PAD组相对于非PAD组,患者年龄大,身高矮,糖尿病病程长,APN水平低(P<0.05)。(2)APN水平与BMI、HbA1c呈负相关,与HDL-C、ABI呈正相关;ABI与年龄、LDL-C、糖尿病病程呈负相关,与APN呈正相关(P<0.05)。(3)BMI、HDL-C、ABI为影响APN的独立相关因素(P<0.05);年龄和APN是影响ABI的独立相关因素(P<0.05)。结论 T2DM患者APN水平与ABI呈独立正相关,APN是PAD重要预测因子。

Objective To study the correlation between serum adiponectin level and the ankle brachial index(ABI) in T2DM,and to explore the related factors for adiponectin and ABI.Methods According to ABI,118 T2DM patients were divided into peripheral arterial disease(PAD) group and non-PAD group.Adiponectin and other clinical parameters were measured.Results(1) PAD group had older age,lower height,longer duration of diabetes,and lower levels of adiponectin as compared to non-PAD group(P<0.05).(2) Serum adiponectin level was negatively correlated with BMI,HbA1c and positively correlated with HDL-C and ABI.ABI was negatively correlated with age,LDL and the duration of DM,and positively correlated with adiponectin(P<0.05).(3) Adiponectin was independently associated with BMI,HDL,ABI(P<0.05);ABI was independently associated with age and adiponectin(P<0.05).Conclusion Serum adiponectin level in T2DM is independently positively associated with ABI,and adiponectin is an important predictor of PAD.