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DPP-4抑制剂保护β细胞功能的作用 被引量：6

DPP-4 inhibitors:study progress of the preservation of pancreatic β-cells
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摘要 胰岛β细胞受损是T2DM发病的关键因素。β细胞受损包括分泌功能受损和数量减少。新诊断T2DM后及早使用DPP-4抑制剂可有效保护β细胞,甚至逆转β细胞分泌功能的丧失,延缓糖尿病病程进展。 There is a progressive deterioration of β-cell function and mass in type 2 diabetes. DPP-4 inhibitor therapy started soon after diagnosis of type 2 diabetes could preserve and even reverse the progressive loss of insulin secretary capacity that is the fundamental cause of type 2 diabetes.
作者 邹大进
机构地区 长海医院内分泌科
出处 《中国糖尿病杂志》 CAS CSCD 北大核心 2012年第8期634-637,共4页 Chinese Journal of Diabetes
关键词 Β细胞 胰岛素 DPP-4抑制剂 糖尿病 2型 β cell Insulin DPP-4 inhibitor Diabetes mellitus, type 2
分类号 R587.1 [医药卫生—内分泌]
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参考文献18

  • 1Matthews DR, Cull CA, Stratton IM, et al. UKPDS 26: Sulphonylurea failure in non-insulin-dependent diabetic patients over six years. UK Prospective Diabetes Study (UKPDS) Group. Diabet Med, 1998, 15:297-303.
  • 2U.K. prospective diabetes study 16. Overview of 6 years therapy of type II diabetes: a progressive disease U.K. Prospective Diabetes Study Group. Diabetes, 1995, 44: 1249-1258.
  • 3Butler AE, Janson J, Bonner-Weir S. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes, 2003,52:102-110.
  • 4Maedler K, Spinas GA, Lehmann R, et al. Glucose inducesbeta-cell apoptosis via upregulation of the Fas receptor in human islets. Diabetes, 2001,50: 1683-1690.
  • 5Grill V, Bj6rklund A. Overstimulation and beta-cell function. Diabetes. 2001,50 (Suppl) 1 : S122-S124.
  • 6Donath MY, Ehses JA, Maedler K. Mechanisms of beta-cell death in type 2 diabetes. Diabetes, 2005,54 (Suppl 2) : S108- Sl13.
  • 7Hull RL, Westermarrk GT, Westermark P, et al. Islet amyloid., a critical entity in the pathogenesis of type 2 diabetes. J Clin Endocr inoI Metah, 2004, 89: 3629-3643.
  • 8Stephens L A, Thomas H E, Kay T W, et al. Protection of NITI pancreatic beta-cells from immune attack by inhibition of NF-KAPPA B. J Autoimmun, 1997, 10:293-298.
  • 9Marc Y, Joachim S, Kathrin M, et al. Inflammatory mediators and islet cell failure: a link between type 1 and type 2 diabetes. J Mol Med,2003:455-470.
  • 10Ahren B. Autonomic regulation of islet hormone secretion-- implications for health and disease. Diabetologia, 2000,43 :393- 410.

同被引文献25

  • 1钱菜立;项坤三;陈家伟.中国糖尿病防治指南(2004版)[M].
  • 2Sivitz WI. Lipotoxicity and glucotoxicity in type 2 diabetes, Effects ondevelopment and progression [ J ]. Postgrad Med,2001,109 (4) :55.
  • 3Ryan EA ,Imes S ,Wallace C. Sh0rt-term intensive insulin therapy- in newly diagnosed type 2 diabetes [ J ]. Diabetes Care, 2004,27 (5) :1028.
  • 4Aaboe K, Knop FK, Vilsbll T, et al. Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improve glucose and non-glucose induced insulin secretion in patients with type 2 diabetes mellitus [ J ]. Diabetes Obes Metab, 2010,12(4) :323.
  • 5GUTHRIE RM. Evolving therapeutic options for type 2 diabetes mellitus : an overview [ J ]. Postgrad Med,2012,124 (6) : 82.
  • 6中华医学会糖尿病学分会.中国糖尿病防治指南2010[S].2010.
  • 7Raraty MG, Conner S, Criddle DN, et al. Acute pancreatitis and organfailure : pathophysiology, natural history, and man- agement strategies[ J]. Curr Gas Rep,2004, (6) :99 - 103.
  • 8Aaboe K, Knop FK, Vilsbll T, et al. Twelve weeks treatment with the DPP -4 inhibitor, sitagliptin, prevents degradation of peptide YY and improve glucose and non - glucose induced insulin secretion in patients with type 2 diabetes mellitus [ J ]. Diabetes Obes Metab,2010,12 (4) : 323.
  • 9Aschner P, Katzerff HL, Guo H, et al. Efficacy and safety of monotherapy of sitagliptin compared with metformin in pa- tients with type 2 diabetes [ J ]. Diabetes Obes Metab,2010, 12(3) :252 -261.
  • 10张儒雅,陆菊明.DPP-4抑制剂在2型糖尿病治疗中的应用[J].中华内分泌代谢杂志,2011,27(1):101-104. 被引量：75

引证文献6

二级引证文献24

中国糖尿病杂志
2012年 第8期

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