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香烟提取物对牙周成纤维细胞中MMP-8表达的影响 被引量：1

The Impact of Cigarette Smoke Extract on Periodontal Fibroblast MMP-8 Expression
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摘要 目的研究香烟提取物对原代培养的牙周成纤维细胞中MMP-8表达的影响。方法取原代培养的牙周成纤维细胞,分别设立空白对照组及香烟提取物干预组,培养24h后,分别收集细胞裂解液,进行Western blot检测,并通过灰度值比较分析MMP-8的表达情况。结果经分析发现,香烟提取物干预组的MMP-8的表达明显高于空白对照组,二者之间有统计学差异。结论香烟提取物干预牙周成纤维细胞后,可使MMP-8的表达升高,从而说明吸烟可能通过上调MMP-8的表达加重牙周组织的破坏。 Objective To investigate the expression of MMP-8 in periodontal fibroblast cells after affected by CSE. Method The periodontal fibroblast cells were classified into control and CSE interfering groups.After incubation for 24h,cell lysates were collected for western blot analyse. Result In CSE interfering groups, the expression of MMP-8 was higher than control groups. Conclusion CSE can upregulate the expression of MMP-8 which may destroy the periodontal tissues.
作者 杨新玲
机构地区 山东省荣军总医院
出处 《中国医药指南》 2012年第21期30-31,共2页 Guide of China Medicine
关键词 牙周炎 MMP-8 吸烟 Periodontitis MMP-8 Smoking
分类号 R781.4 [医药卫生—口腔医学]
  • 相关文献

参考文献8

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二级参考文献35

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共引文献8

同被引文献19

  • 1孙晓强,刘晓勇,王瑛弢,王凤光,汪育苗.吸烟对牙周炎患者牙龈组织上皮和血管的影响[J].首都医科大学学报,2006,27(3):286-289. 被引量：10
  • 2武影,束蓉,沈敏华,葛琳华.牙周炎患者非刺激性全唾液中IL-1β和MMP-8的检测及意义[J].上海口腔医学,2007,16(2):127-130. 被引量：6
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中国医药指南
2012年 第21期

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