卡托普利与螺内酯联合用药方案治疗原发性高血压合并心力衰竭的临床观察

Clinical effect of captopril combined with spironolactone in the treatment of essential hypertension Complicated by heart failure

目的观察卡托普利与螺内酯联合用药方案治疗原发性高血压合并心力衰竭的临床效果。方法将96例原发性高血压合并心力衰竭患者随机分为观察组和对照组各48例。2组均给予基础治疗+地高辛+硝酸异山梨醇酯+呋塞米+卡托普利治疗,观察组在上述基础上加用螺内酯口服治疗。观察并比较2组治疗前后临床症状及血压、心功能改善情况。结果观察组总有效率为70.83%,高于对照组的58.33%,差异有统计学意义(P<0.05)。2组治疗后血压SBP、DBP、心率(HR)低于治疗前,心功能分级优于治疗前,左室射血分数高于治疗前;且观察组血压及心功能变化优于对照组,差异均有统计学意义(P<0.05和P<0.01)。结论卡托普利与螺内酯联合用药方案治疗原发性高血压合并心力衰竭的临床效果好,不良反应少。

Objective To observe the clinical effect of captopril combined with spironolactone in the treatment of essential hypertension Complicated by heart failure.Methods 96 cases patients with essential hypertension complicated by heart failure were randomly divided into observation group and control group,each of 48 cases.Both of 2 groups were given digoxin,isosorbide dinitrate,furosemide and captopril as a primary treatment,and the observation group based on this were added with spironolactone.Observed and compared clinical symptoms,blood pressure and heart function of 2 groups before and after treatment.Results The total effect rate of the observation group（70.83%） was higher than that of the control group（58.33%）,the difference was statistically significant（P〈0.05）.After treatment,the blood pressure,heart rate of 2 groups were lower than that before treatment;the cardiac function classification of 2 groups were better than that before treatment;Left ventricular ejection fraction of 2 groups were higher than that before treatment;the blood pressure and the change of cardiac function of the observation group were better than that of the control group,the differences were statistically significant（P〈0.05 and P〈0.01）.Conclusion The clinical effect of captopril combined with spironolactone in the treatment of essential hypertension complicated by heart failure is well and has fewer side effects.