摘要
目的采用Meta分析的方法评价TNF-α基因中–308G/A位点多态性和前列腺癌易感性之间的关系,为进一步阐明前列腺癌发病的分子机制及筛查前列腺癌高风险人群提供参考。方法计算机检索PubMed(1950~2011)、EMbase(1990~2011)、CNKI、CBM、VIP和WanFang Data,按照纳入与排除标准筛出关于TNF-α-308位点多态性与前列腺癌相关性的病例-对照研究或队列研究,检索时限均为从建库至2012年1月。在提取数据和评价纳入研究的方法学质量后,采用RevMan 5.1.4和Stata 11.0软件进行统计分析。结果共纳入11个研究,4 919例前列腺癌患者,5 210例健康对照。Meta分析结果显示:①前列腺癌组与对照组中基因型AA vs.GG[OR=0.92,95%CI(0.71,1.20),P=0.55]、GA vs.GG[OR=1.11,95%CI(0.90,1.37),P=0.33)、AA vs.GG+GA[OR=0.91,95%CI(0.70,1.18),P=0.47)、GA+AA vs.GG[OR=1.11,95%CI(0.90,1.36),P=0.33)、等位基因A vs.G[OR=1.07,95%CI(0.91,1.26),P=0.39]与前列腺癌易感性之间均无相关性;②以人种为亚组进行分层分析,发现TNF-α–308位点的多样性在不同人种中也无明显相关性(P>0.05)。结论现有证据显示,TNF-α–308位点等位基因和基因型可能与前列腺癌易感性无关。由于纳入研究数量有限,上述结论尚需开展更多高质量、大样本的随机对照试验加以验证。
Objective To comprehensively evaluate the association between TNF-α gene 308 G/A polymorphism and the risk of prostate cancer.Methods A meta-analysis was performed to analyze the association between 308 G/A polymorphism and the risk of prostate cancer risk.Results A total of 11 case-control studies(4 919 cases and 5 210 controls) were included in this meta-analysis.The result showed no statistically significant differences in all genotype distribution between prostate cancer cases and controls: dominant model(OR=1.11,95%CI 0.90 to 1.36,P=0.33),recessive model(OR=0.91,95%CI 0.70 to 1.18,P=0.47),GA versus GG(OR=1.11,95%CI 0.90 to 1.37,P=0.33),AA versus GG(OR=0.92,95%CI 0.71 to 1.20,P=0.55),A versus G(OR=1.07,95%CI 0.91 to 1.26,P=0.39).In the subgroup analysis by ethnicity,no statistically differences were found between prostate cancer cases and controls.Conclusion This results of meta-analysis suggests that TNF-α gene –308G/A polymorphism may not be a risk factor of prostate cancer.Due to the limited quantity of the includied studies,further studies are needed to validate the above conclusion.
出处
《中国循证医学杂志》
CSCD
2012年第8期1030-1034,共5页
Chinese Journal of Evidence-based Medicine