曲唑酮联合低剂量西地那非治疗合并勃起功能障碍的早泄患者的临床观察

Effect of trazodone combined with low-dose sildenafil in the treatment for premature ejaculation complicated with erectile dysfunction

目的:评价曲唑酮联合低剂量西地那非治疗合并勃起功能障碍(ED)的早泄患者的临床效果。方法:80例诊断为合并ED的早泄患者分为实验组(曲唑酮联合低剂量西地那非)和对照组(单用曲唑酮),每组40例。实验组每天睡前服用曲唑酮50 mg,西地那非25mg,疗程2个月。对照组每天睡前服用曲唑酮50 mg,疗程2个月。以治疗前后IIEF-5评分和阴道内射精潜伏期(IELT)的变化来评价治疗效果,进行组内和组间比较,同时记录夫妻对性生活的满意情况,Tess副反应量表评定药物的不良反应。结果:实验组勃起功能改善35例,有效率为87.5%;早泄改善33例,有效率为82.5%;性生活满意率60%;对照组勃起功能改善20例,有效率为50%;早泄改善18例,有效率为45%;性生活满意率60%。在勃起功能、早泄改善和性生活满意度方面差异均有显著统计学意义(P<0.01),两组的不良反应轻,无停药者。结论:对合并ED的早泄患者采取曲唑酮联合低剂量西地那非治疗安全、有效、耐受性好。

Objectives： To evaluate the clinical efficacy and safety of trazedone combined with low- dose sildenafil in the treatment for premature ejaculation（PE） complicated with erectile dysfunction（ED）. Methods： Eighty patients with PE and con- comitant ED were randomly and equally divided into two groups： a experimental group（ trazodone and low - dose sildenalil） and a control group（trazodone only）, 40 cases for each group. The ~perimental group received trazodone 50 mg and sildenafil 25 mg daily before bedtime, and the control group received trazodone 50 mg daily before bedtime. The treatment for both groups lasted 2 months. The evaluation of the efficacy depended on the changes in IIEF-5 and intravaginal ejaculator,/latency time（IELT） be- fore and after the treatment. At the same time, we made inter - and intra - group comparisons, recorded satisfaction level of sex- ual life, and evaluated the adverse effect of the treatment with TESS. Results： In the experimental group,35 patients had their ED symptom improved with an effective rate of 87.5%, and 33 patients had their PE improved with an effective rate of 82.5%, and the percentage of the patient showing satisfaction with their sexual life was 60%. As to the control group, 20 patients had their ED symptom improved with an effective rate of 50%, 18 patients had their PE improved with an effective rate of 45%, and the percentage of the patient showing satisfaction with their sexual life was 60%. In terms of each of the three indexes, there was a significant difference between the two groups （P 〈 0.01 ）. For all the patients, only mild side effects were recorded, and none withdrew from the treatment. Conclusion： To patients with PE and concomitant ED, the key to the treatment was to improve their erectile function, for which the combination of trazodone and low - dose sildenafil worked better than trazodone alone.