糖耐量减低患者餐后2小时尿微量白蛋白、尿糖的改变及意义

The change and clinical significance of postprandial 2h urinary microalbumin and glucose in IGT patients

目的 :了解与正常成人相比糖耐量减低 (IGT)患者餐后 2小时尿微量白蛋白、尿糖的改变及意义。方法 :对 36例 IGT患者、 30例正常成人于早晨空腹抽血查 FBG、BUN及 Cr、血脂后排尿 ,口服 75 g葡萄糖粉 ,2小时后查血糖、尿糖、尿白蛋白、尿 Cr。结果 :IGT组与正常对照组相比餐后 2小时尿 Glu/ Cr及尿 Alb/ Cr均明显升高 ;IGT患者中 ,血脂增高者与血脂正常者相比餐后 2小时尿 Glu/ Cr较高 ,但无统计学意义 (P >0 .0 5 ) ,而餐后 2小时尿 Alb/ Cr却明显升高 (P <0 .0 5 )。结论 :IGT阶段已开始出现肾小球硬化的微血管病变 ;IGT患者的肾损害中并不单纯有微血管的病变 ,高脂血症、肾小动脉硬化等大血管病变也是肾损害的重要因素。

Objective:To investigate the change and clinical significance of postprandial 2h urinary microalbumin and glucose in IGT patients Methods:After being examined the fasting blood glucose、BUN、Cr and lipid in the morning,36 cases of IGT patients and 30 cases of controls urinated and took orally 75g glucose,then were examined the blood glucose、urinary glucose(Glu)、urinary microalbumin(Alb)、urinary Cr two hours later Results:The postprandial 2h urinary Glu/Cr and Alb/Cr in IGT group were significantly higher than controls And in IGT group,the postprandial 2h urinary Alb/Cr and Glu/Cr in the hyperlipidemia patients were all higher than non hyperlipidemia ones,but it had no significance in statistics on the contrast in the postprandial 2h urinary Glu/Cr Conclusion:It's beginnng to appear the glomerular sclerosis of microvascular complications during the IGT state Not only microvascular complications,but macrovascular complications such as hyperlipidemia and renal arteriole sclerosis also were the important factors in the renal damages on IGT