多药耐药菌感染监测与预防控制策略

Surveillance for multidrug-resistant organisms infections and strategies for prevention and control

目的监测多药耐药菌(MDROs)感染情况,为临床有效控制MDROs感染提供依据。方法 2009-2010年医院微生物室检测到的MDROs,采取前瞻性监测方法,隔离MDROs感染患者,控制MDROs的蔓延。结果 2010年MDROs感染例数较2009年升高,由311例上升至435例,增加124例;MDROs感染率较2009年升高,由1.70%上升至2.14%(χ2=9.95,P=0.00);MDROs社区感染率较2009年增高,由1.47%上升至1.91%(χ2=11.18,P=0.00),两年MDROs医院感染率一致,均为0.23%(χ2=0.00,P=0.97);两年医院感染构成比差异无统计学意义。结论前瞻性监测不能降低MDROs医院感染率,需制定更科学的预防控制措施。

OBJECTIVE To provide bases for effective clinical control of MDROs infections by monitoring muhidrug-resistant organism infections. METHODS MDROs isolated from microorganism room of the hospital during 2009--2010 were selected, by the means of prospective surveillance, MDROs-positive patients were put in isolation so that to prevent the spread of MDROs. RESULTS The number of patients with MDROs infection rose from 311 cases in 2009 to 435 cases in 2010, increasing by 124 cases3 the rate of MDROs infections was increased as compared with that in 2009, rising from 1. 70% to 2. 14% （;g2 = 9. 95, P= 0. 00）3 the rate of community infections caused by MDROs rose as compared with that in 2009, increasing from 1.47% to 1.91%（x2 =11.18, P=0.00）3 it shared a similar rate of hospital MDROs infections, which was 0.23% （x2 =0.00,P=0.97）3 the difference in the distribution of nosocomial infections in the two years was not statistically significant. CONCLUSION Prospective surveillance can not help to reduce the rate of MDROs infections, it is necessary to develop more scientific preventive measures.