卡泊芬净经验性治疗白血病并发真菌感染的临床疗效分析与评价

Efficacy of caspofungin in empirical treatment of fungal infections patients with leukemia

目的评估卡泊芬净经验性治疗白血病并发真菌感染的疗效分析及不良反应。方法选择2009年1月-2011年10月医院白血病并发真菌感染的50例患者,分为卡泊芬净及伊曲康唑两组,每组25例,卡泊芬净组给予卡泊芬净经验性治疗,伊曲康唑组给予伊曲康唑抗真菌治疗,两组治疗时间均持续至体温恢复正常后5d或疗程达14d或连续痰涂片阴性后3d;对两种药物的疗效和不良反应进行观察和评价。结果卡泊芬净和伊曲康唑在治疗白血病并发真菌感染中,总有效率分别为88.0%和64.0%,差异有统计学意义(P<0.05),两组比较后发现,卡泊芬净较伊曲康唑不良反应少,耐受性好。结论在白血病并发真菌感染的治疗中,卡泊芬净较伊曲康唑疗效更好,不良反应更少,患者耐受性更好,是治疗白血病并发真菌感染安全有效的药物。

OBJECTIVE To evaluate the safety and efficacy of caspofungin in treatment of fungal infections patients with leukemia and the adverse reactions. METHODS A total of 50 leukemia patients with fungal infections who received caspofungin or itraconazole for treatment were divided into the caspofungin group and the itraconazole group with 25 patients in each, the treatment continued until 5 days after the body temperature returned back to normal, or the course reached to 14 days or the sputum smear were negative for 3 consecutive days; the efficacy of the two drugs and the adverse reactions were observed and the evaluated. RRESULTS In the treatment of leukemia with fungal infections by using caspofungin and itraconazole, the total effective rates were 88.0% and 64.0%, respectively, the differences were statistically significant （P〈0.05）, this study found that caspofungin had less adverse reactio＇ns than did the itraconazole with good tolerance. CONCLUSION Caspofungin, with less adverse reaction and better tolerance to the patients, is a safe and effective drug for the treatment of leukemia patients with fungal infections.