鲍氏不动杆菌感染的临床分布及耐药性分析

Clinical distribution and drug resistance of Acinetobacter baumanniiinfections

目的了解医院鲍氏不动杆菌感染的临床分布及耐药性,为临床合理用药提供参考。方法应用纸片琼脂扩散试验对153株鲍氏不动杆菌进行药敏分析。结果 2010年1月-2011年6月医院住院患者共中分离鲍氏不动杆菌153株,主要来自痰标本,占88.89%,主要引起重症监护病房和神经外科患者的下呼吸道感染;该菌对头孢哌酮/舒巴坦敏感率最高,达72.55%,对米诺环素敏感率为60.78%,对阿米卡星、哌拉西林/舒巴坦和亚胺培南敏感率分别为45.10%、37.25%和33.99%;而对哌拉西林、氨曲南、头孢吡肟、左氧氟沙星的敏感率均<20.00%。结论鲍氏不动杆菌感染以重症监护病房和神经外科最常见;该菌对头孢哌酮/舒巴坦敏感率最高。

OBJECTIVE To understand the clinical distribution and drug resistance of clinical isolates of Acineto- bacter baumannii so as to provide reference for reasonable use of antibiotics. METHODS Disk agar diffusion test was performed for drug susceptibility of 153 A. baumannii isolates. RESULTS A total of 153 strains of A. bau- mannii were isolated from Jan 2010 to Jun 2011, which were mainly isolated from sputum specimens, accounting for 88.89 %, those isolates mainly caused lower respiratory tract infections in ICU and neurosurgery department; the susceptibility rates of the isolates to cefoperozone/sulbactum were the highest, reaching to 72.55%, 60.8% to minocycline; the susceptibility rates to amikacin, piperacillin/sulbactam, and imipenem were 45.10%, 37.25%, and 33.99%, respectively; the susceptibility rates to piperacillin, aztreonam, cefepime, and levofloxacin were below 20.00 %. CONCLUSION A. baurnannii infection is most common in ICU and neurosurgery department; the susceptibility rate of the isolate to ceforperezone/sulbactam is the highest.