洛阳市儿童医院多药耐药菌感染的分布及耐药性分析

Multidrug-resistant bacteria infections in children′s hospital of Luoyang and analysis of drug resistance

目的分析多药耐药菌分布、耐药性及易感因素,指导临床用药。方法对2010年度监测到的全院多药耐药菌及药敏结果进行分析,同时追踪其易感因素。结果共分离出病原菌1033株,其中多药耐药菌461株,检出率为44.6%;分离到的多药耐药菌主要为产ESBLs大肠埃希菌及耐甲氧西林凝固酶阴性葡萄球菌(MRCNS),分别占42.5%、26.2%;多药耐药菌对大多数常用抗菌药物耐药。结论结合医院药物敏感试验,婴幼儿革兰阴性多药耐药菌感染宜选用头孢哌酮/舒巴坦、亚胺培南;革兰阳性多药耐药菌感染宜选用夫西地酸、替考拉宁、万古霉素。

OBJECTIVE To analyze the distribution, drug resistance, and susceptible factors of multidrug-resistant organisms so as to guide the clinical treatment. METHODS The multidrug-resistant organisms monitored in 2010 and drug susceptibility testing were analyzed, at the same time the susceptible factors were tracked. RESULTS A total of 1033 strains were isolated, there were 461 strains of multidrug-resistant bacteria with the detection rate of 44.6% the multidrug-resistant bacteria isolated were mainly the ESBLs-produeing Escherichia coli and methicil- 1in-resistant coagulase-negative Staphylococcus, accounting %or 42. 5% and 26. 2% ; multidrug-resis%ant strains were resistant to common antibiotics. CONCLUSION According to the drug susceptibility testing, cefoperazone/ sulbactam and imipenem are suitable for the treatment of gram-negative multidrug-resistant organism infections in infants; fusidate, vancomycin, and teicoplanin are suitable for the treatment of gram-positive multidrug-resistant organism infections.