泌尿生殖道患者支原体属感染的鉴定及药敏分析

Identification of urogenital tract Mycoplasmainfections and analysis of drug susceptibility

目的了解泌尿生殖道患者解脲脲支原体(Uu)、人支原体(Mh)感染对抗菌药物的耐药性,为临床诊断及治疗提供试验数椐。方法对557例泌尿生殖道患者进行支原体属培养鉴定及14种抗菌药物敏感性试验。结果 557例患者中,支原体属阳性350例,阳性率为62.84%;Uu、Mh及Uu+Mh混合感染的阳性率分别为58.53%、2.87%及1.44%,男性感染率为43.17%,女性感染率为76.36%;支原体属对14种抗菌药物敏感性较高的是多西环素、米诺环素、加替沙星、甲砜霉素、交沙霉素、罗红霉素、阿奇霉素、培氟沙星;药物敏感性较低的是头孢哌酮/舒巴坦、克林霉素、左氧氟沙星、头孢曲松、地红霉素和环丙沙星。结论支原体属药敏结果各地均不完全相同,对于支原体属感染应尽量做培养及药敏试验,为临床提供帮助。

OBJECTIVE To investigate the drug resistance of Ureaplasma Urealyticurn （Uu） and Mycoplasrn horni- nis （Mh） causing urogenital tract infections, so as to provide experimental data for clinical diagnosis and treatment. METHODS Mycoplasma from 557 patients with urogenital tract infections were cultured, the drug susceptibility testing for 14 antibiotics was performed. RESULTS Of 557 patients investigated, Mycoplasma were detected in 350 cases with the positive rate of 62.84% ; the positive rates of Uu infection, Mh infection , and Uu ＋Mh mixed infections were 58. 53%, 2. 87%, and 1. 44%. The infection rate of the male was 43. 17%, the female 76.36%; of the 14 antibiotics tested, Mycoplasma were highly susceptible to doxycycline, minocycline, gatifloxacin, thiamphenieol, josamycin, roxithromyein, azithromycin, and pefloxacin; the drug susceptibilities to cefoperazone/sulbactam, elindamycin, levofloxacin, ceftriaxone, erythromycin, and ciprofloxaein were relatively low. CONCLUSION The results of the drug susceptibility testings vary in regions; for Mycoplasma infections, it is necessary to perform the culture and drug susceptibility testing so as to support the clinical practice.