动静脉双途径联合化疗治疗结肠癌肝转移疗效观察

The clinical effects of transcatheter hepatic arterial chemoembolization and systemic chemotherapy for treatment of colorectal cancer with hepatic metastasis

目的 探讨动静脉双途径联合化疗治疗结直肠癌肝转移的临床疗效。方法 50例结肠癌肝转移按治疗方法分为A、B两组,A组采用肝动脉化疗栓塞加静脉全身化疗,B组采用单纯静脉全身化疗,观察两组副反应、肝内病灶大小变化情况及生存率。结果 两组副反应发生率差异无统计学意义（χ2=3.95,P＞0.05）,A组肝内病灶体积缩小或稳定高于B组（P＜0.05）,A组1年、3年生存率分别为84%和64%,明显高于B组的56%和36%（均P＜0.05）。结论 动静脉双途径联合化疗治疗结肠癌肝转移疗效好,副反应少,能明显提高生存率。

Objective To explore the clinical effect of transcatheter hepatic arterial chemoembolization and systemic chemotherapy on colorectal cancer with hepatic metastasis.Methods 50 cases of colon cancer with hepatic metastasis according to treatment methods were divided into A,B group.A group treated by TACE plus intravenous chemotherapy,B group treated by intravenous chemotherapy alone.Side effects,changes in liver tumor size and survival rate were observed.Results The incidence of side effects of two groups had no significant difference（P＞0.05）.A group of liver lesions smaller in size or stable is more than in group B（P＜0.05）.A group of 1 year,3 years survival rate is 84% and 64% respectively,which is higher than B group 56% and 36%（all P＜0.05）.Conclusion Transcatheter hepatic arterial chemoembolization and systemic chemotherapy is a safe and effective treatment of colon cancer with hepatic metastasis,it can obviously raise the survival rate.