乙型肝炎患者血清标志物与HBV-DNA水平的关系探讨

Study of the relationship between HBV serum markers and HBV-DNA level

目的 探讨乙型肝炎（乙肝）患者血清标志物与其HBV-DNA水平之间的关系。方法 选取乙肝患者230例,用ELISA法检测血清标志物,用PCR法检测HBV-DNA水平。结果 在76例HBeAg阳性标本中,HBV-DNA阳性72例,阳性率为94.7%;154例HBeAg阴性标本中,HBV-DNA阳性72例,阳性率为46.7%。HBeAg阳性组与HBeAg阴性组HBV-DNA阳性率差异有统计学意义（P＜0.01）。结论 乙肝患者血清标志物的检测,可以了解HBV在体内的感染情况,不能直接反映HBV在患者体内的复制情况。HBV-DNA水平检测可以更好地反映病毒的复制情况。

Objective To investigate the relationship between hepatitis B markers and HBV-DNA content.Methods 230 cases with hepatitis were selected.ELISA method was used to detect serum markers,PCR method for detecting the content of HBV-DNA.Results In 76cases of HBeAg positive specimens,72 cases were HBV-DNA positive,the positive rate was 94.7%;in 154 patients with HBeAg negative specimens,72 cases were HBV-DNA positive,the positive rate was 46.7%.The difference between HBeAg positive group and HBeAg negative group was statistically different（P＜0.01）.Conclusion In patients with chronic hepatitis B,serum markers reflected,HBV can understand the in vivo infection,cannot directly reflect the in vivo replication of HBV.Detection of HBV-DNA content can better reflect the virus replication.