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乙二醛对染毒大鼠抗氧化酶活力的影响 被引量：1

Effects of Glyoxal on Activities of Anti-oxidase in Blood and Tissues of Rats
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摘要 通过观察乙二醛染毒大鼠血及组织中谷胱甘肽过氧化物酶 (GSH -Px)活力的变化 ,探讨了乙二醛对抗氧化酶活力的影响。经气管灌注法对大鼠染毒 ,测定全血和组织中GSH PxR的活力 ,结果表明在高剂量组全血GSH -Px活力显著低于对照组。乙二醛对全血GSH -Px活力的影响主要表现为降低作用 ,脏器中GSH -Px的活力变化表现为应激性增高趋势 。 Effects of glyoxal on anti oxidase in rats were studied by observing the activity changes of GSH Px in blood and tissues after exposure.Glyoxal was instilled through respiratory track.The activities of GSH Px in blood and tissues were measured.The activities of blood GSH Px of high dose group were significantly lower than that of the controls.Glyoxal exposure inhibited the GSH Px activities of blood,while the effects on tissues were not the same.An increase tendency of GSH Px activities in tissues was observed.In kidney,the increase was significant.
作者 范来富 李富君 李革新 陈爱莉 刘轩军
机构地区 中国医科大学公共卫生学院
出处 《工业卫生与职业病》 CAS CSCD 2000年第4期207-208,共2页 Industrial Health and Occupational Diseases
关键词 乙二醛 谷胱甘肽过氧化物酶 Glyoxal GSH Px Rat
分类号 R135.1 [医药卫生—劳动卫生] R994.6 [医药卫生—毒理学]
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工业卫生与职业病
2000年 第4期

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