血管交联剂预处理异体颈静脉重建大鼠腹主动脉

Reconstruction of Rat Abdominal Aota with Jugular Vein Homografts Pretreated by Polyepoxy Compound

目的评估新型血管交联剂———多聚环氧化合物 (polyepoxycompound ,PC)的应用价值。 方法分别用PC和传统交联剂戊二醛 (glutaraldehyde ,GA)对取自SD大鼠的颈静脉进行预处理 ,并移植于同种大鼠的肾下腹主动脉 ,观察两种静脉植入动脉环境后的组织学变化。 结果两种静脉植入动脉环境后通畅率无统计学差异 (P >0 .0 5 ) ;PC组的瘤样扩张率低于GA组 (P <0 .0 5 ) ;两组内膜愈合过程基本一致 ,移植 2月后内皮细胞覆盖静脉内壁。 结论GA仍是一种效果明确的交联剂 ;PC预处理的静脉有瘤样扩张发生率低、血管柔顺性高、牢度大、较少钙沉积等优点 ,是一种有潜力的交联剂。

Objective To evaluate a new cross-linking reagent — polyepoxy compound(PC) in vivo. Methods To reconstruct abdominal aota with jugular homografts of SD rats (diameter 0.8～ 1.1 mm) pret4reated by glycero polyglycidyl ether(a kind of PC) or glutaraldehyde(GA). Grafts were explanted at different elapsed time, and their histological changes were studied. Results There was no difference between the patencies of the PC and GA prepared homografts (P>0.05), but the incidence of aneurysms in GA is higher than that in PC group (P<0.05). The healing procedures of endothelial cells in two experimental groups were basically same at the end of second month after transplantation. The endothelial cells cover the whole inner wall of the grafts. Conclusion Compaired PC graft with GA graft, it shows that PC are more unbreakable and compliant, lower rate of aneurysms and less calcification. PC might be a potential vessel-crosslink-reagent.