中晚期非小细胞肺癌的疗效分析

Comparative Study of the Theraputic Effects on Medium-Term and Late NSCLC

目的确定放疗中化疗是否较放疗后化疗在治疗中晚期非小细胞肺癌中有效率、生存率等方面更好。方法将 1993年 2 1例中晚期非小细胞肺癌患者随机分成 2组。组 1为放疗中化疗 (n =11) ,组 2放疗后化疗 (n =10 ) ,化疗方案为CAP和EP交替使用 ,1次 / 3周。所有患者化疗次数均为 10次。肺部肿瘤放疗的剂量均为 6 0Gy ,30次 ,6周内完成。 结果完全缓解加部分缓解 :组 1为 90 .9% ,组 2为 40 .0 % ,两组有显著差异 (P <0 .0 5 )。生存率 :组 1中 1年生存率 45 .4% ,2年生存率 18.1% ,3年生存率 9.1% ,无 4年生存率。组 2中 1年生存率 40 % ,2年生存率 10 % ,无 3年生存率 ,两组无显著差异 (P >0 .0 5 )。结论放疗中化疗比放疗后化疗有较高的有效率 ,但未能证明放疗中化疗能改善生存率。

Objective Studied 21 cases of medium-term and late NSCLC to assess whether it is better with chemotherapy in course of radiotherapy than that after radiotherapy for efficiency and survival rate. Methods In 1993, 21 patients were divided into 2 groups randomly, patients of group 1(n=11) underwent chemotherapy in coruse of radiotherapy: performed within a week radiotherapy begun, with CAP and EP plans in turn once per 3 weeks.Patients of group 2(n=10) underwent chemotherapy after radiotherapy, with CAP and EP plans in turn once per 3 weeks. The frequency of chemotherapy for all was 10 times. The quantity of radiation was 60Gy, 30times in 6 weeks. Results (CR+PR)of group 1 was 90.9%, that of group 2 was 40.0% (P<0.05). Survival rate by Kaplan-Meiere method:For group 1,1 year (45.4%), 2 years(18.1%), 3 years(9.1%), 4 years (0); for group 2, 1 year (40%), 2 years (10%), 3 years(0). By Log-rank test, (X 2=1.156,P>0.05), no significance. Conclusion According to the result, chemotherapy in course of radiotherapy has higher effective ratio than that after radiotherapy. But it's not conformed that the former could improve the survival rate.