摘要
正常细胞周期调控机制的丧失是肿瘤的特征 ,这为发展靶向关卡调控为基础的新的肿瘤治疗策略提供了许多机会。这些策略包括对细胞周期关卡阻止的诱导 ,阻滞肿瘤细胞在治疗剂敏感的细胞周期阶段 ,和针对特异性细胞周期调控因子的靶治疗。细胞周期和细胞周期关卡因子为新型抗癌药物提供了丰富的靶位 ,这些药物主要是周期素依赖性激酶抑制剂和关卡取消剂 ,它们可以增强DNA损伤剂的抗肿瘤活性。
The disruption of normal cell cycle regulation,which is the hallmark of cancer,presents numerous opportunities for targeting checkpoint controls to develop new therapeutic strategies for this diseaseSuch strategies include induction of checkpoint arrest leading to apoptosis,arrest of cancer cells in stages of the cell cycle which may sensitize them to treatment with other therapeutic agents,and targeting of therapies toward specific regulatory components of cell cycleCell cycle machinery and components of cell cycle checkpoint have provided a wealth of target for novel anticancer drugsChief among these is the cyclindependent kinase inhibitors and checkpoint abrogatorsBoth cyclindependent kinase inhibitors and checkpoint abrogators have the potential for significant synergism with DNAdamaging agent
关键词
抗癌药物
细胞周期关卡
治疗
肿瘤
细胞调亡
anticancer drug
cell cycle checkpoint
treatment
neoplasm
apoptosis
