柯萨奇B组病毒感染与扩张型心肌病发病关系的研究

The study on Relationship between infection Coxsackievirus group B(CBV) and Dilated Cardiomyopathy

为探讨柯萨奇B组病毒 (CoxsackievirusgroupB ,CBV)与扩张型心肌病 (dilatedcardiomyopathy ,DCM )发病的关系 ,应用逆转录 聚合酶链反应 (RT PCR)及酶联免疫吸附试验(ELISA)检查 39例扩张型心肌病患者 (DCM组 )外周血中CBV RNA、血清中CBV IgM。结果表明 ,DCM组外周血CBV RNA ,血清中CBV IgM阳性率分别为 41 0 2 %、30 76 % ,对照组分别为 7 6 % ,2 5 6 % ,两组比较差别有显著性意义 (P <0 0 5 )。结果提示 ,柯萨奇B组病毒感染和 (或 )持续感染是引起扩张型心肌病的重要原因。

Mao Ling,et al.Virus Research Insititute,Hubei Medical University(Wuhan 430071) To investing the relation between infection of coxsackievirus gruoup B and dilated cardiomyopathy.Methods:The 39 case dilated cardiomyopthy patient's CBV RNA in peripheral blood cells and CBV IgM in the sera by RT PCR and ELISA respectively,So were the 26 case health people as control group.Resultes:dill.ated cardiomyopahty patient's positive rates of CBV RNA in peripheral blood cells and CBV IgM in the sera are 41\^02%、30 75%,respectively and the control group's positive rates are 7 6%,2 56%,respectively.The positive rates are significartly different between two groups(P<0 05).Conclusions:CBV infection plays an important role in dilated cardiomyopathy.