丙氨酸氨基转移酶检测值及不合格率在献血人群中的分布研究

Distribution of alanine aminostransferase activity and unqualified rate in blood donors

目的研究丙氨酸氨基转移酶(ALT)检测值及不合格率在献血人群中的分布,对献血员进行ALT检测这一最受争议的问题提供详细的调查资料。方法用EpiDate软件建立河北省邯郸市中心血站无偿献血者年龄、性别、献血次数、职业、文化程度和乙型肝炎病毒表面抗原(HBsAg)、抗丙型肝炎病毒抗体(抗-HCV)、抗人类免疫缺陷病毒抗体(抗-HIV)和梅毒等检测情况及相关ALT检测值的数据库,共10 844例,通过相关软件对其进行分析。结果 ALT检测值除不同性别、检测结果(阴性或阳性)等方面比较,差异无统计学意义(P>0.05)外,在不同层次献血人群其他项目分布等方面比较,差异均有统计学意义(P<0.05)。而ALT不合格率除不同文化程度方面比较,差异无统计学意义外(P>0.05),在不同层次献血人群其他项目分布等方面比较,差异均有统计学意义(P<0.05)。结论 ALT检测值和不合格率在不同献血人群中的分布比较,大部分差异有统计学意义,应在实际工作中根据情况避免因单项ALT不合格导致的血液报废,在现有条件下尽可能避免浪费血源。

Objective To study the distribution of alanine aminostransferase（ALT） activity and unqualified rate in blood donors to provide detailed survey data to ALT detection,the most controversial issues involved in blood donors.Methods The database of 10 844 subjects was built by Epidate,including age,sex,blood donation frequency,career,education level and the detection result of HBsAg,anti HCV,anti HIV,syphilis and ALT,and all data were analyzed by relevant softwares.Results ALT value had not statistical difference in sex and detection results（negative or positive）（P〈0.05）,but had difference in other population level distribution（P〉0.05）.ALT unqualified rate had not statistical difference between different education levels（P〈0.05）,but had difference in others（P〉0.05）.Conclusion ALT value and unqualified rate might be different in most donors.In actual works,the unqualified blood donors for single ALT abnormality should be eliminated to avoid waste of blood.