摘要
研究表明 ,端粒短缩、端粒酶异常活化与肿瘤的发生发展有密切关系 ,端粒酶可作为肿瘤早期诊断的生物学标志物。甲状腺癌组织中存在端粒酶表达 ,其阳性表达率与癌细胞分化程度有关 ,甲状腺细针穿刺标本端粒酶活性检测有助于良恶性疾病的鉴别。端粒酶抑制剂有望成为肿瘤广谱治疗的新途径。
出处
《国外医学（内分泌学分册）》
2000年第4期188-191,共4页
Foreign Medical Sciences(Section of Endocrinology)
参考文献14
-
1RhyuM.Telomeres,telomeraseandimmortality[J].JNCI,1995,87:884～894.
-
2KimNW,PiatyszekMA,ProuseKR,etal.Specificassociationofhumantelomeraseactivitywithimmortalcellsandcancer[J].Science,1994,266:2011～2015.
-
3BlascoMA,FunkW,VilleponteauB,etal.FunctionalcharacterizationanddevelopmentregulationofmousetelomeraseRNA[J].Science,1995,269:1267～1270.
-
4UmbrichtCB,SajiM,WestraWH,etal.Telomeraseactivity:amarkertodistinguishfollicularthyroidadenomafromcarcinoma[J].CancerRes,1997,57:2144～2147.
-
5OkayasuI,OsakabeT,FujiwaraM,etal.Significantcorrelationoftelomeraseactivityinthyroidpapillarycarcinomaswithcelldifferentiation,proliferationandextrathyroidalextension[J].JpnJCancerRes,1997,88:965～970.
-
6HaugonBR,NawazS,MarkhamN,etal.Telomeraseactivityinbenignandmalignantthyroidtumors[J].Thyroid,1997,7:337～342.
-
7ChengAJ,LinJD,ChangT,etal.Telomeraseactivityinbenignandmalignantthyroidtissues[J].BrJCancer,1998,77:2177～2180.
-
8BroussetP,ChaoucheN,LepratF,etal.Telomeraseactivityinhumanthyroidcarcinomasoriginatingfromthefollicularcells[J].JClinEndocrinolMetab,1997,82:4214～4216.
-
9SajiM,WestraWH,ChenH,etal.Telomeraseactivityinthedifferentialdiagnosisofpapillarycarcinomaofthethyroid[J].Surgery,1997,122:1137～1140.
-
10YashimaK,VuitchF,GazdarAF,etal.Telomeraseactivityinbenignandmalignantthyroiddiseases[J].Surgery,1997,122:1141～1146.
同被引文献10
-
1李靖若,牛韵韵,张云汉.贲门癌组织端粒酶活性和端粒酶RNA表达的检测[J].郑州大学学报（医学版）,2004,39(6):1020-1022. 被引量：1
-
2姜汉国,高嵋,唐慰萍,李飞虹,蔡琼珍.VEGF、VEGF-C和VEGF-D在甲状腺乳头状癌组织中的表达及意义[J].癌症,2005,24(9):1136-1139. 被引量：11
-
3Churchill A E, Biggs P M. Agent of Marek's disease in tissue culture [J]. Nature,1967,215-258.
-
4Hazerianm K, Solomn J J, Witter R I, et al. Studies on the etiology of Marek's disease. Finding of a herpes virus in cell culture [J]. Proc Soc Exp Biol Med,1968,127-177.
-
5Calnek B W, Witter R I. Marek's Disease of Poultry [M]. Ames,USA:Iowa State University Press,1997.369-400.
-
6Harley C B, Sherwood S W. Telomerase,checkpoints and cancer [J]. Cancer Surv,1997,29:263-284.
-
7Kim N W, Piatyszek M A, Prowse K R, et al. Speci- fic association of human telomerase activity with immortal cells and cancer [J]. Sci,1994,266:2011-2021.
-
8Hiyama E, Gallahon L,Kataoka T,et al. Telomerase activity in human breast tumors [J]. J Natl Cancer Inst,1996,88(2):116-122.
-
9Cheung A N, Zhang D K, Liu Y, et al. Telomerase activity in gestational trophoblastic disease [J]. J Clin Pathol,1999,52(8):588-592.
-
10Mokbel K M, Parris C N, Ghilchik M, et al. Telome- rase activity and lymphovascular invasion in breast cancer [J]. Eur J Surg Oncol,2000,26(1):30-33.
-
1周家华,杨德同,张丽珊.胰腺肿瘤分子生物学研究进展[J].中华肝胆外科杂志,2000,6(2):150-152. 被引量：1
-
2李亚力.端粒酶抑制与肿瘤治疗的关系[J].中华医学写作杂志,2001,8(2):240-240.
-
3汪素文,袁孟彪.端粒酶抑制与肿瘤治疗[J].第三军医大学学报,2001,23(A07):118-119.
-
4李晓兰,聂大平,李振国.乳癌细针穿刺标本与术后病理组织三项生物学指标的比较[J].齐鲁医学杂志,2002,17(2):108-109.
-
5洪玉蓉,罗志艳,闻卿,鄢曹鑫,吴宁波,周小兵,莫国强,黄品同.甲状腺结节细针穿刺标本BRAF V600E基因突变检测的临床应用[J].中华超声影像学杂志,2015,24(8):671-674. 被引量：18
-
6彭猛青,王绪,罗涛,刘德林,陈玉玲,毛筱芬,朱述阳,邵华军,马淑华.端粒酶活性和p16基因甲基化检测对肺癌早期诊断的价值[J].实用放射学杂志,2002,18(4):257-260.
-
7刘晓彤,王春涛,秦玲.乳腺癌细针穿刺标本与术后活检组织生物学指标的比较分析[J].武警医学,2006,17(1):67-68. 被引量：1
-
8金顺钱,张伟,滕茂芳,张智慧,刘毅,李茉,曲平,王淑珍,金玉生,王洪平,潘秦镜,刘树范.乳腺癌细针穿刺标本中端粒酶检测的诊断意义[J].中华病理学杂志,1999,28(5):334-336. 被引量：9
-
9季洪爱,金行藻,周晓军,祁正茂.细针吸取细胞学和组织学对肝细胞癌的诊断[J].医学研究生学报,1997,10(4):333-336.
-
10墙华.端粒酶活性抑制与肿瘤治疗的研究进展[J].宁夏医学院学报,2005,27(4):327-329.
