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内源性哇巴因的来源及其分泌调节 被引量：1

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摘要 内源性哇巴因 (EO)是新近发现的一种类固醇激素 ,具有重要的病理和生理学意义。应用细胞培养、离体及在体动物实验的研究结果以及大量的临床证据表明 ,EO可能是由肾上腺皮质分泌的 ,但也有研究提示它可能来源于下丘脑。EO的分泌受摄盐量、血容量、肾素 血管紧张素 醛固酮系统、中枢神经系统、体内胰岛素水平以及缺氧等多种因素的调节 ,对机体水、电解质平衡的稳定以及血压调控等方面具有重要作用。
作者 原卫清 王颢 吕卓人
机构地区 西安医科大学第一附属医院心内科
出处 《国外医学（内分泌学分册）》 2000年第4期201-205,共5页 Foreign Medical Sciences(Section of Endocrinology)
关键词 哇巴因 类固醇激素 肾上腺皮质
分类号 R335 [医药卫生—人体生理学]
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参考文献20

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  • 2Butt AN, Semra YK, Ho CS, et al. Effect of high salt intake on plasma and tissueconcentration of endogenous ouabain-like substance in the rat[J]. Life Sci, 1997,61:2367～2373.
  • 3Hamlyn JM, Lu ZR, Manunta P, et al. Observations on the nature, biosynthesis,secretion and significance of endogenous ouabain [J]. Clin Exp Hypert, 1998,20:523～533.
  • 4Schneider R, Wray V, Nimtz M, et al. Bovine adrenals contain,in addition toouabain, a second inhibitor of the sodium pump[J].J Biol Chem, 1998,273:784～792.
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同被引文献38

  • 1Ferrandi M, Manunta P, Rivera R, et al. Role of the ouabain- like factor and Na-K pump in rat and human genetic hyper- tension[ J]. Clin Exp Hypertens, 1998,20(5 - 6) :629 - 639.
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  • 4Hamlyn JM, Blaustein MP, Bova S, et al. Identification and characterization of a ouabain-like compound from human plas- ma[J]. Proc Natl Acad Sci U S A, 1991, 88 (14): 6 259 -6 263.
  • 5Ferrandi M, Minotti E, Florio M, et al. Age-dependency and dietary influence on the hypothalamic ouabain-like factor in Milan hypertensive rats [J]. J Hypertens, 1995,13 (12 Pt 2) : 1571-1574.
  • 6Takahashi H, Ihara N,Terano Y, et al. Ouabain-like immuno- reactive substances exist in the hypothalamus and the adrenal medulla in rats [ J ]. Pathophysiology, 1994,1 ( 1 ) :25 - 28.
  • 7Schneider R, Wray V, Nimtz M, et al. Bovine adrenals con- tain,in addition to ouabain, a second inhibitor of the sodium pump [ J ]. J Biol Chem, 1998,273 ( 2 ) : 784 - 792.
  • 8Butt AN, Semra YK, Ho CS, et al. Effect of high salt intake on plasma and tissue concentration of endogenous ouabain-like substance in the rat [ J]. Life Sci, 1997, 61 (24): 2 367 -2 373.
  • 9Hamlyn JM, Lu ZR, Manunta P, et al. Observations on the na- ture, biosynthesis, secretion and significance of endogenous ouabain [ J ]. Clin Exp Hypertens, 1998,20 (5 - 6) :523 - 533.
  • 10Rossi G, Manunta P, Hamlyn JM, et al. Immunoreactive en-dogenous ouabain in primary aldosteronism and essential hy- pertension:relationship with plasma renin, aldosterone and blood pressure levels [ J ]. J Hypertens, 1995, 13 ( 10 ) : 1 181-1 191.

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国外医学（内分泌学分册）
2000年 第4期

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