利多卡因降低神经外科危重病人应激反应的研究

The research of using lidocain to reduce the dying patients stress reaction in neurosurgical department

目的 对利多卡因降低神经外科危重病人应激过度所致损伤的临床疗效进行研究。方法 40例神经外科危重病人 ,在基础治疗的同时 2 0例采用利多卡因治疗 (治疗组 ) ,2 0例按以往常规治疗 (对照组 )。对两组激素水平 (胃泌素、内皮素、抗利尿激素 )、血糖、胃液的pH进行测定 ,观察两组的临床疗效。结果 治疗组胃泌素、内皮素、抗利尿激素、血糖明显下降 ;对照组胃泌素、内皮素、抗利尿激素、血糖均高于正常水平。结论 利多卡因的应用有效降低神经外科危重病人的应激损伤 ,提高临床疗效 。

Objective To research the dying patients clinical effect by using lidocain to reduce their stress reaction in neurosurgical department. Methods Divide 40 dying patients into 2 groups. 20 cases, as treatment group, were used lidocain. 20 cases, as control group, were not used lidocain. The hormone level. (Gas, ET, ADH), blood glycose, hytrochloric acid in gastric juice and the clinical characteristics of two groups were observed and recorded.Results The level of Gas, ET, ADH, blood glucose of dying patients in treatment group decreased obviously after treatment. and the stress reaction were reduced effectively. On the contrary, all effects in control group were higher than normal level, and the patients' stress reaction can not be controlled effectively. Conclusions Lidocain can reduce the dying patients' stress reaction in neurosurgical department' so it can improve the clinical effect and reduce the death rate.