165例肾病综合征临床病理分析

CLINICO-PATHOLOGICAL STUDIES IN 165 CASES OF NEPHROTIC SYNDROM

本文对经肾活检的165例肾病综合征(NS)患者进行临床病理分析。系膜增殖性肾炎为NS最常见的病理类型,占39.4%;其次为膜增殖性肾炎,占17.5%。病理类型与皮质激素及免疫抑制剂疗效关系密切。微小病变型肾病疗效最好,其次为系膜增殖性肾炎,膜增殖性肾炎及局灶性节段性肾小球硬化症疗效差。NS Ⅰ型疗效优于NSⅡ型,P<0.02。系膜增殖性肾炎病理损伤轻者疗效优于损伤重者,P<0.05。

The clinical and pathological correlation in 165 cases nephrotic syndrom was studied Mesangial proliferative GN was the most frequeut pathological type of NS (39.4%) and the second was membranoproliferative GN (17.5%). There was a close relation between pathological types therapeutic efficacy of corticoid and immunosuppressant. Minimal nephropathy responded best to the therapy, mesangial proliferative GN was better response to the therapy hereas the membranoprohferative GN and focal segmental glomerulosclerosis GN had the worst. NS type I had better effect than type Ⅱ (P<0.02). There was better effect in the mild cases than the serious cases in patients with mesangial proliferative GN (P<0.05).