摘要
肾脏是维持体液和电解质稳态最主要的器官,肾功能不全患者的抗生素体内分布、药物清除率和排泄等药动学参数均可发生不同程度的改变,并可因此影响患者的肾功能。本文综述肾功能不全患者的抗生素合理选用以及针对不同肾功能患者的剂量调整。
The kidney is responsible for maintaining body fluid and electrolyte homeostasis. For the patients withunderlying renal insufficiency, their pharmacokinetics of antibiotics including distribution, clearance and excretion, largely varied. Some changes in pharmacokinetics of antibiotics can impact therapeutic result in patients with renal insufficiency. This review describes rational application of antibiotics for renal insufficiency patients.
出处
《世界临床药物》
CAS
2012年第8期464-467,共4页
World Clinical Drug
关键词
肾功能不全
抗生素
合理用药
renal insufficiency
antibiotics
rational drug use
