绞股蓝总皂甙免疫调节作用的研究

Study on the Immunomodulatory Action of the Total Saponin of Gynostemma pentaphylla

本研究对湖南省绥宁产绞股蓝总皂甙进行了免疫药理研究。结果显示该总皂甙对环磷酰胺所致小鼠免疫功能低下有显著拮抗作用;对自然杀伤细胞活性有显著增强作用;对正常小鼠有一定双向免疫调节作用;并具有抗疲劳、耐缺氧等多种功效,值得开发利用。

The specimen of the total saponin for this experimental study was extracted from Gynostemma pentaphylla growing in Suining county in Hunan province.Weight of immune organs.content of anti-SRBC hemolysin,rate of special Ea-RFC formation and percentage of NK cell activity had been employed for the study as experimental indices,both the normal healthy mice and the mice with immunity impairment due to Cyclophosphamidum(Cy) management as experimental models.The results of the study exhibited:(1) The total saponin of Gynostemma pentaphylla could markedly act against the immunity inhibition due to Cy management in the experimental animals,showing a variant recovery in mice treated by Cy in weight of the immune organs,content of hemolysin, forming rate of Ea-RFC and unequivocally elevating NK cell activity,by significant difference in comparison with the Cy control groups (P<0.05～0.01).(2)The total saponin showed a definiteness of bidirective immunomodulatory action in normal healthy mice,recovering the immune indices to normal value from either originally lower or higher than the medium figure,by significant difference in comparison with the Cy control groups (P<0.05～0.01).(3)The total saponin had actions to prevent from fatigue and to tolerate hypoxia under usual atmospheric pressure.The above description indicates that the total saponin of Gynostemma pentaphylla is a better immunomodulator,seems to be like the actions of some Chinese drugs,for example,Panax ginseng,Astragalus membranaceus etc.