矽肺早期诊断的生物标志物CC16和SP-D

Biomarkers for early diagnosis of silicosis:Clara cell protein and surfactant protein D

矽肺是由于在生产过程中长期吸入含有游离二氧化硅粉尘而引起以肺组织纤维化为主的全身性疾病,是尘肺中危害最严重的职业病之一。其病理演化过程为与炎性有关的纤维化反应。近几年一些学者在研究矽肺的致病机制过程中发现CC16、SP-D的抗炎及抗纤维化等作用在矽肺发生发展过程中起到重要作用,并可能成为矽肺早期诊断的生物标志物。本文就它们在矽肺诊断中的价值作一简单介绍。

Silicosis is a systemic disease with diffuse pulmonary fibrosis caused by long-term inhalation and retention of industrial dust contained free SiO2 in lungs, which is one of the most serious and hazardous occupational diseases in pneumonoconiosis. The pathological process showed that silicosis seems a fibrosis reaction related to inflammatory response. In recent years, some scholars discovered that CC16 and SP-D had anti-inflammatory and antifibrotic effects, which might play an important role in the occurrence and development processes of silicosis and probablely be the potential biomakers for the early diagnosis of silicosis. This paper will give a brief introduction on the value of them in this field.