摘要
本文报告用雷公藤甲素(简称甲素)和雷公藤醋酸乙酯提取物(简称提取物)进行临床对照观察,治疗类风湿性关节炎(RA)各15例,旨在进一步探讨雷公藤治疗 RA的主要有效成份。结果表明:两组治疗结果经统计学处理无显著性差异。甲素组对心脏有明显损伤,提取物组则少见。初步认为甲素系雷公藤治疗 RA 的主要有效成份之一,亦是雷公藤中主要有毒成份之一,并提示雷公藤治疗 RA 是以甲素为主的多种成份的协同作用。
It was satisfactory using the ethyl acetate extract of Tripterygiurn wilfordii(TW)to treat rheumatoid arthritis(RA).The results showed that the ethyl acetate extract of TW was the effective component part of TW.Although the therapeutic effect of 15 cases with RA cured by triptolide was as effective as the ethyl acetate extract of TW,triptolide could impair some patients'hearts.This suggested that triptolide was one of the main effective elements of TW,but it was also one of the main toxic elements.Clinical research indicated that:(1)the effect of TW in treating RA was the synergistic action of elements with triptolide as the main;(2)triptolide may act as at major standard of controlling the quality of the preparation of TW and assure clinical use safely.
