摘要
应用放射免疫测定法测定了急性实验性脑缺血大白兔脑缺血前后血浆和脑脊液中强啡肽 A1-13样免疫活性物质(ir-Dyn A1-13)含量的变化。发现脑缺血后血浆和脑脊液中 ir-Dyn A1-13的含量明显升高(P<0.01);应用川芎治疗能显著地改善血浆和脑脊液中 ir-Dyn A1-13含量变化,并能显著地减轻大白兔脑组织缺血性损害和神经系统功能障碍。本文进一步探讨了脑缺血的病理生理机制及川芎防治脑缺血的作用机理。
By occluding the bilateral carotid arteries of rabbits to produce bilateral partial cerebral ischemia,and by using radioimmunoassays to measure the levels of dynorphin Al-13.1ike immunor- eactivity(ir-Dyn Al-13)in plasma and cerebrospinal fluid(CSF),the authors find that the levels of ir-Dyn Al-13 in plasma and CSF have significantly increased(P<0.01)after cerebral ischemia appears.The result of the Ligusticum wallichii Franch(Ligusticum)pretreatment to the test-group shows a definite improvement of the changes of ir-Dyn Al-13 levels in plasma and CSF,The severity of brain ischemic damage and neurologic dysfunction in Ligusticum-treated animals is lighter than that of saline-treated group,too.In this study,some new approaches are explored to explain the pathophysiology of cerebral ischemia and the mechanisms by which Ligusticum prevents and treats cerebral ischemia.
