摘要
本研究将麻疹活疫苗注入家兔主胰管及耳缘静脉,14及48小时血清淀粉酶明显升高,血小板聚集率显著增强,与两个对照组相比均有显著差异(P<0.05～0.01)。胰腺可见明显瘀血及点片状出血。大黄治疗组24及48小时血清淀粉酶及血小板聚集升高均受到阻抑,胰腺瘀血、出血亦减轻。结果提示病毒对胰腺的侵袭是发生出血型胰腺炎的因素之一;大黄是治疗出血型胰腺炎的有效药物。
The living measles vaccine was injected into both of the main pancreatic duct and the ear vein of the rabbits in the model group.The serum amylase was significantly higher than that of the control saline group(P<0.001 after 24h;P<0.05 after 48h).The aggregation function of platelets were increased after 24h(P<0.01,P<0.01)and 48h(P<0.01,P<0.05)as compared with both two control groups.The blood stasis and hemorrhage of pancreases were observed in the model group. In the treatment group with Rhubarb the increase of serum amylase Was much less marked than the control(P<0.001 after 24h,P<0.05 after 48h).The platelet aggregation reactivity was inhibited(P< 0.01 after 24h,P<0.05 after 48h).The blood stasis and hemorrhage of pancreases were less evident. The results suggested that:(1)the virus may be one of pathogenetic factor of the hemorrhagic pancreatitis;(2)the rhubarb was effective in the treatment of hemorrhagic pancreatitis under our experimental conditions.
