摘要
本文报告了应用克糖灵治疗Ⅱ型糖尿病38例,通过对服用该药患者治疗前后血中葡萄糖、胰岛素、C 肽、胰高糖素等的观察,探讨克糖灵对Ⅱ型糖尿病胰岛 A、B 细胞功能的影响。结果表明:克糖灵对Ⅱ型糖尿病不仅可明显地降低血糖,而且有显著改善糖耐量作用。对于肥胖Ⅱ型糖尿病可促进胰岛 B 细胞分泌胰岛素增加,同时可能抑制胰岛A细胞分泌胰高糖素或改善了 A 细胞对血糖感受能力等一系列作用来实现糖尿病的治疗作用。认为克糖灵在目前Ⅱ型糖尿病治疗领域中不失为一有效且较理想的药物。
Radioimmunoassay methods were modified for insulin(IRI),C-peptide(IRCP)and glucagon(IRG) in the clinical investigation on normal subjects and 38 patients with non-insulin-dependent diabetes mellitus(NIDDM).In the control group,the peaks of glucose and IRI appeared 1 hour after glucose was taken.IRCP peak,however,appeared 1 hour later.IRG showed its maximum value on fasting and then reached its lowest point at the second hour after glucose loading.The authors'interests were focused on the changes of blood glucose,IRI,IRCP,and IRG in oral glucose tolerance test (OGTT)before and after Ke-Tang-Ling(KTL)was administered in NIDDM.The results demon- strate that the glucose levels and undercure areas at various phases in OGTT were significantly decreased(P<0.01)in comparison of before and after the treatment with KTL in NIDDM(including obese and non-obese groups).In non-obese group,however,IRI,IRCP,and their undercure were remarkably increased(P<0.01).In obese group their values were decreased.It suggests that KTL plays a therapeutic role in decreasing blood glucose in non-obese NIDDM.The mechanism involved in this process may be related to its stimulating effect.IRG levels were decreased also(P<0.01)after the treatment with KTL in both obese and non-obese NIDDM,suggesting an inhibitory effect on glucagon secretion from α cells in pancrease.
