摘要
甲胎蛋白(AFP)作为一种肝癌诊断的标志物,一直受到人们的广泛关注。通过对AFP衍生肽的研究,已经发现AFP衍生肽作为抗原表位在肝癌的生长和发展过程中对T细胞有刺激作用。我们通过阐述AFP衍生肽抗原表位的分布及其对肝细胞癌中T细胞活动的影响,进一步说明AFP衍生肽作为抗原表位在肝癌免疫治疗中的作用。
As a biomarker of diagnosis in liver cancer, alpha-fetoprotein（AFP） has been highlighted recently. And many studies addressed AFP-derived peptides as immunologic responders in hepatocellular carcinoma and their uses in the study and generation of AFP-peptide sensitized T cells directed against hepatoma ceils. The roles of AFP-derived peptide epitopes to T cell activities during the course of hepatoma immunotherapies were further discussed.
出处
《生物技术通讯》
CAS
2012年第4期601-603,共3页
Letters in Biotechnology
基金
黑龙江省发展高新技术产业专项(FW11C201)
大庆市科技计划(scyc-2010-62)
大庆高新区科技专项(DQGX10ZS005)
关键词
甲胎蛋白
衍生肽
抗原表位
肝癌
免疫治疗
alpha-fetoprotein
derived peptides
epitopes
hepatocellular carcinoma
immunotherapy
