摘要
雌激素在抗皮肤老化过程中起着重要作用,其通过与皮肤上的雌激素受体结合发挥作用。不同亚型的雌激素受体介导不同的信号传导通路。皮肤细胞中雌激素受体的分布不仅存在数量差异更有类别差异,这些差异性和雌激素受体本身的基因多态性决定了其作用的多效性。简要综述了不同亚型雌激素受体在各皮肤解剖层次中抗老化作用的研究进展。
The estrogen plays an important role in skin antiaging. The effects of estrogen are predominantly mediated through the estrogen receptors（ER）. The ER isoforms regulate multiple signaling pathways. The distribution of ER in skin cell not only have difference in quantity but in type. The differentation and gene polymorphism have lead to the multiple effect of ER. In this paper, the anti aging ability of ER isoforms which are in different layer of skin will be summarized and discussed.
出处
《生物技术通讯》
CAS
2012年第4期606-609,共4页
Letters in Biotechnology
关键词
雌激素受体
皮肤老化
信号通路
estrogen receptor
skin antiaging
signaling pathway
