多重耐药菌的定植与感染

Colonization and infection of multidrug-resistant organisms

多重耐药菌在重症监护病房的检出率日益增高，确定其为定植还是感染对临床合理使用抗生素、减少耐药菌产生、降低院内感染率十分重要。但如何区分定植与感染是困惑临床医师的一大难题，除了将细菌培养结果与临床症状、体征相结合外，尚应更多地采用一些客观指标来指导临床。本文将对多重耐药菌的定植与感染的定义、关系、判断等作一阐述。

There are much more multidrug-resistant organisms （MDRO） in the intensive care unit than ever. If the doctors could distinguish the colonization from infection of MDRO, they can make right deci- sion on the rational clinical use of antibiotics to reduce resistant organisms and nosocomial infection. Howev- er,it＇s a confused problem for clinicians to distinguish between colonization and infection. Bacterial culture combined with clinical symptoms and signs maybe helpful, but it is limited. There should be more objective indicators. This article was aimed to state the definition and relationship between colonization and infection, and how to determine the colonization and infection of MDRO.